2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO1/TDO-IN-9

IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) with IC50s of <1 μM. IDO1/TDO-IN-9 inhibits the activity of IDO1 and TDO, blocking tryptophan degradation to kynurenine, restoring immune activity in the tumor microenvironment, and suppressing tumor growth. IDO1/TDO-IN-9 is promising for research of cancers.

For research use only. We do not sell to patients.

IDO1/TDO-IN-9

IDO1/TDO-IN-9 Chemical Structure

CAS No. : 1878200-88-4

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Based on 1 publication(s) in Google Scholar

IDO1/TDO-IN-9 Related Antibodies

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View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

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IDO1 IDO2 IDO

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Description

IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) with IC50s of <1 μM. IDO1/TDO-IN-9 inhibits the activity of IDO1 and TDO, blocking tryptophan degradation to kynurenine, restoring immune activity in the tumor microenvironment, and suppressing tumor growth. IDO1/TDO-IN-9 is promising for research of cancers[1].

Molecular Weight

187.56

Formula

C6H3ClFN3O
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

NC1=NOC2=NC(Cl)=C(F)C=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (533.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3316 mL 26.6581 mL 53.3163 mL
5 mM 1.0663 mL 5.3316 mL 10.6633 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3316 mL 26.6581 mL 53.3163 mL 133.2907 mL
5 mM 1.0663 mL 5.3316 mL 10.6633 mL 26.6581 mL
10 mM 0.5332 mL 2.6658 mL 5.3316 mL 13.3291 mL
15 mM 0.3554 mL 1.7772 mL 3.5544 mL 8.8860 mL
20 mM 0.2666 mL 1.3329 mL 2.6658 mL 6.6645 mL
25 mM 0.2133 mL 1.0663 mL 2.1327 mL 5.3316 mL
30 mM 0.1777 mL 0.8886 mL 1.7772 mL 4.4430 mL
40 mM 0.1333 mL 0.6665 mL 1.3329 mL 3.3323 mL
50 mM 0.1066 mL 0.5332 mL 1.0663 mL 2.6658 mL
60 mM 0.0889 mL 0.4443 mL 0.8886 mL 2.2215 mL
80 mM 0.0666 mL 0.3332 mL 0.6665 mL 1.6661 mL
100 mM 0.0533 mL 0.2666 mL 0.5332 mL 1.3329 mL
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IDO1/TDO-IN-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1/TDO-IN-91878200-88-4Indoleamine 2,3-Dioxygenase (IDO)IDO1TDOcancersInhibitorinhibitorinhibit

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