2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Epigenetics
  3. EGFR AMPK
  4. EGFR-IN-146

EGFR-IN-146 is an EGFR inhibitor that can inhibit the EGFR signaling pathway and improve insulin sensitivity by activating the AMPK pathway, which can effectively reduce blood sugar levels and body weight. EGFR-IN-146 has great potential in the study of diabetes and obesity.

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EGFR-IN-146 Chemical Structure

EGFR-IN-146 Chemical Structure

CAS No. : 166039-38-9

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EGFR-IN-146 Related Antibodies

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

EGFR-IN-146 is an EGFR inhibitor that can inhibit the EGFR signaling pathway and improve insulin sensitivity by activating the AMPK pathway, which can effectively reduce blood sugar levels and body weight. EGFR-IN-146 has great potential in the study of diabetes and obesity[1].

In Vitro

EGFR-IN-146 (Compound 53) (10 μM) effectively promotes glucose absorption and plays a role in lowering blood sugar in the C2C12 cell model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-146 Related Antibodies
Molecular Weight

312.37

Formula

C20H16N4
CAS No.
SMILES

C1(CNC2=C3C=CC=CC3=NC(C4=CC=CC=C4)=N2)=CC=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-146 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-146166039-38-9EGFRAMPKEpidermal growth factor receptorErbB-1HER1AMP-activated protein kinasediabetesobesityC2C12 cellsInhibitorinhibitorinhibit

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