2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphoglycerate Kinase (PGK) Cuproptosis
  4. PGK1-IN-2

PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 μM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma.

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PGK1-IN-2

PGK1-IN-2 Chemical Structure

CAS No. : 3054148-68-1

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PGK1-IN-2 Related Antibodies

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PGK1

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Description

PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 μM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma[1].

IC50 & Target[1]

PGK1

8.24 μM (IC50)

Molecular Weight

416.49

Formula

C20H24N4O4S
CAS No.
SMILES

COCCCCNC(C1=NC(C2N(C3=NC=CC=C3OC)C(CS2)=O)=CC=C1)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PGK1-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PGK1-IN-23054148-68-1Phosphoglycerate Kinase (PGK)CuproptosisPhosphoglycerate KinaseOsteosarcomaPhosphoglycerate Kinase 1 (PGK1)Thiazolidin-4-oneDrug DiscoveryStructure-Activity Relationship (SAR)Antitumor ActivityGlycolysisTarget IdentificationInhibitorinhibitorinhibit

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