Phosphoglycerate Kinase (PGK)

Phosphoglycerate Kinase (PGK) is a key enzyme involved in glycolysis and gluconeogenesis. Currently, there are two isoenzymes of Phosphoglycerate Kinase, PGK1 and PGK2. Phosphoglycerate Kinase (PGK) catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP, producing 3-phosphoglycerate and ATP. This reaction is the first step in ATP production during glycolysis. Abnormal function of Phosphoglycerate Kinase (PGK) can disrupt cellular energy metabolism, thereby triggering and influencing the occurrence and development of various diseases, such as cancer, hemolytic anemia, neuromuscular dysfunction, etc^[1].