2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphoglycerate Kinase (PGK)
  5. Phosphoglycerate Kinase (PGK) Inhibitor

Phosphoglycerate Kinase (PGK) Inhibitor

Phosphoglycerate Kinase (PGK) Isoform Comparison

Phosphoglycerate Kinase (PGK) Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-N8540
    Ilicicolin H
    		Inhibitor
    Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection.