2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Phosphoglycerate Kinase (PGK) Fungal Apoptosis
  4. Ilicicolin H

Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection.

For research use only. We do not sell to patients.

Ilicicolin H

Ilicicolin H Chemical Structure

CAS No. : 12689-26-8

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Ilicicolin H Related Antibodies

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Description

Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection[1][2].

IC50 & Target[1]

PGK1

9.02 μM (IC50)

In Vitro

Ilicicolin H (1-8 μM, 24 h) induces apoptosis and increases active cleaved fragments of Caspase-3, Caspase-9 levels in HepG2 and Huh7 cells[1].
Ilicicolin H (2-8 μM, 6 h) reduces the levels of HIF-1α induced by CoCl 2 and the phosphorylation levels of PDHK1 at T338 induced by EGF in HepG2 cells[1].
Ilicicolin H (1-8 μM, 6 h) inhibits lactate production and glucose uptake in HepG2 cells[1].
Ilicicolin H shows anti-fungal activity against C. albicans (0.04 to 0.31 μg/mL), other Candida species (0.01 to 5.0 μg/mL), Cryptococcus (MIC = 0.1-1.56 μg/mL) and A. fumigatus (MIC = 0.08 μg/mL)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ilicicolin H Related Antibodies

Apoptosis Analysis[1]

Cell Line: HepG2 and Huh7 cells
Concentration: 1, 2, 4 and 8 μM
Incubation Time: 24 h
Result: Increased C-Cas3, C-Cas9, and C-Parp levels.
Increased apoptotic cells.
In Vivo

Ilicicolin H (6.25-50 mg/kg, p.o., daily for 2 days) reduces C. albicans burden in C. albicans infected mice models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C. albicans infected mice models[2]
Dosage: 6.25, 12.5, 25 and 50 mg/kg
Administration: Orally administration, daily for 2 days
Result: Reduced C. albicans burden.
Molecular Weight

433.54

Formula

C27H31NO4
CAS No.
SMILES

O=C1C(C([C@H]2[C@H](/C=C/C)[C@@]3([H])C[C@@H](C)CC[C@]3([H])C(C)=C2)=O)=C(O)C(C4=CC=C(O)C=C4)=CN1
Structure Classification
Initial Source

Campylocarpon sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ilicicolin H Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilicicolin H12689-26-8Phosphoglycerate Kinase (PGK)FungalApoptosisPhosphoglycerate KinasePGK1Bc1C. albicansCryptococcusHepG2Huh7Inhibitorinhibitorinhibit

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