2. Neuronal Signaling
  3. Monoamine Oxidase Cholinesterase (ChE)
  4. BChE/MAO-B-IN-2

BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD).

For research use only. We do not sell to patients.

BChE/MAO-B-IN-2

BChE/MAO-B-IN-2 Chemical Structure

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BChE/MAO-B-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Monoamine Oxidase Isoform Specific Products:

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MAO-A MAO-B

View All Cholinesterase (ChE) Isoform Specific Products:

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AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD)[1].

IC50 & Target[1]

MAO-B

0.45 μM (IC50)

MAO-B

0.08 μM (Ki)

hBCHE

0.05 μM (IC50)

hBCHE

0.01 μM (IC50)

MAO-A

5.00 μM (IC50)

MAO-A

1.20 μM (Ki)

AChE

0.8 μM (Ki)

AChE

2 μM (EC50)

In Vitro

BChE/MAO-B-IN-2 (Compound 4a-S) shows DPPH radical scavenging activity (IC50 = 3.57 mM), antioxidant activity in the CUPRAC assay (IC50 = 33 μM) and superoxide anion scavenging capacity (IC50 = 24 μM)[1].
MAO-B-IN-48 (1-25 μM) does not exhibit cytotoxic effects on HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BChE/MAO-B-IN-2 Related Antibodies
In Vivo

BChE/MAO-B-IN-2 (20 mg/kg, i.g., 1 week) ameliorates the cognitive impairment induced by AlCl3 in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 40mg/kg of AlCl3 was administered intraperitoneally (i.p.) to male Balb/c mice for 30 days[1]
Dosage: 20 mg/kg
Administration: i.g. for 1 week
Result: Ameliorated the cognitive impairment induced by AlCl3 in mice.
Molecular Weight

286.37

Formula

C17H22N2O2
SMILES

C#CCN[C@H](C1=CC(OC(N2CCCCC2)=O)=CC=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BChE/MAO-B-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE/MAO-B-IN-2Monoamine OxidaseCholinesterase (ChE)MAOAlzheimer's diseaseMAO-BBChEβ-amyloid peptidesInhibitorinhibitorinhibit

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