2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP DNA/RNA Synthesis Apoptosis
  4. BER-IN-1

BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β,δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR)-proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib. BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer.

For research use only. We do not sell to patients.

BER-IN-1

BER-IN-1 Chemical Structure

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BER-IN-1 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β,δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR)-proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib. BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer[1].

IC50 & Target[1]

PARP-1

 

In Vitro

BER-IN-1 (Compound BA-6) shows IC50 of 10.92 μM for MDA-MB-231, 6.37 μM for HeLa, 7.76 μM for SKOV3 and 5.53 μM for OVCAR3BRCA1−/− cells[1].
BER-IN-1 (0.7-50 μM, 24-72 h) significantly reduces cell viability companied with Olaparib (HY-10162) in MDA-MB-231, HeLa and OVCAR3BRCA1−/− cells[1].
BER-IN-1 (5-10 μM) inhibits colony formation companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
BER-IN-1 (5-50 μM) increased prominent β-elimination products and induces DNA DSBs companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
BER-IN-1 (5-10 μM, 24 h) induces S-phase arrest and apoptosis companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BER-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-231, HeLa and OVCAR3BRCA1−/− cells
Concentration: 0.7, 1.5, 3.1, 6.2, 12.5, 25 and 50 μM
Incubation Time: 24 or 72 h, companied with Olaparib (0.15-200 μM)
Result: Significantly reduced cell viability.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 and HeLa cancer cells
Concentration: 5 and 10 μM
Incubation Time: 24 h, companied with Olaparib (5-10 μM)
Result: Increased cells in the G2/M phase and S-phase arrest.
Molecular Weight

243.31

Formula

C13H17N5
SMILES

NC1=CC=C2N=C(N(C)CCCN3C)C3=NC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BER-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BER-IN-1PARPDNA/RNA SynthesisApoptosispoly ADP ribose polymerase BEROlaparibDNAMDA-MB-231HeLaSKOV3Breast cancerCervical cancerOvarian cancerInhibitorinhibitorinhibit

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