IL1R1 Antibody (YA3797)

IL1R1 Antibody (YA3797) is a mouse-derived and non-conjugated IgG1 antibody, targeting to IL1R1. It can be applicated for WB, FC, ELISA assays, in the background of human.

IL1R1, a receptor for interleukin-1A (IL1A), interleukin-1B (IL1B), and interleukin-1 receptor antagonist (IL1RN), forms a high-affinity complex with the coreceptor IL1RAP upon ligand binding. This complex mediates interleukin-1-dependent activation of signaling pathways such as NF-kappa-B and MAPK. The signaling cascade involves the recruitment of adapter molecules, including TOLLIP, MYD88, and IRAK1 or IRAK2, through the TIR domains of the receptor/coreceptor subunits. IL1R1 binds ligands with comparable affinity, and the interaction with antagonist IL1RN prevents the association with IL1RAP, thus inhibiting the formation of a signaling complex. Furthermore, IL1R1 is implicated in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.

P14778

Predicted band size: 65 kDa; Observed band size: 72 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human IL1R1 (AA: 18-167) expressed in E. Coli.