2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE7-IN-4

PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases.

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PDE7-IN-4 Chemical Structure

PDE7-IN-4 Chemical Structure

CAS No. : 18741-24-7

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Based on 1 publication(s) in Google Scholar

PDE7-IN-4 Related Antibodies

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Description

PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases[1].

Molecular Weight

254.31

Formula

C14H10N2OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

S=C(N1)N(C2=CC=CC=C2)C(C3=C1C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (196.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9322 mL 19.6610 mL 39.3221 mL
5 mM 0.7864 mL 3.9322 mL 7.8644 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9322 mL 19.6610 mL 39.3221 mL 98.3052 mL
5 mM 0.7864 mL 3.9322 mL 7.8644 mL 19.6610 mL
10 mM 0.3932 mL 1.9661 mL 3.9322 mL 9.8305 mL
15 mM 0.2621 mL 1.3107 mL 2.6215 mL 6.5537 mL
20 mM 0.1966 mL 0.9831 mL 1.9661 mL 4.9153 mL
25 mM 0.1573 mL 0.7864 mL 1.5729 mL 3.9322 mL
30 mM 0.1311 mL 0.6554 mL 1.3107 mL 3.2768 mL
40 mM 0.0983 mL 0.4915 mL 0.9831 mL 2.4576 mL
50 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9661 mL
60 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6384 mL
80 mM 0.0492 mL 0.2458 mL 0.4915 mL 1.2288 mL
100 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.9831 mL
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PDE7-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE7-IN-418741-24-7Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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