GPER/Bcl-2-IN-1

Cat. No.: HY-174338: Data Sheet Handling Instructions
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GPER/Bcl-2 Inhibitor is a GPER/Bcl-2 inhibitor. GPER/Bcl-2 Inhibitor can inhibit the proliferation and neurospheres formation of glioblastoma cells. GPER/Bcl-2 Inhibitor can be used for the study of glioblastoma multiforme (GBM).

For research use only. We do not sell to patients.

GPER/Bcl-2-IN-1 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

GPER/Bcl-2 Inhibitor (L-37) (0-140 μM, 48 h) exhibits IC₅₀ values of 40.72 μM (LN-18), 39.78 μM (U373), 109.7 μM (BJ), and 23.86 μM (MCF-10A), respectively^[1].
GPER/Bcl-2 Inhibitor (0-10 μM, 4-5 days) can inhibit the proliferation and neurosphere formation of Gli4 glioblastoma stem cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Gli4 cell
Concentration:	0, 1 and 10 μM
Incubation Time:	5 (in differentiation media) or 4 days (in proliferation media)
Result:	Inhibited the cell viability in differentiation media. Reduced the cell count in proliferation media with round bottom plates.

Molecular Weight

587.87

Formula

C₂₆H₂₀BrClN₂O₅S

SMILES

ClC1=CC=C(S(NC(C2=CC=C3C([C@H](C=CC4)[C@H]4[C@H](C5=C(Br)C=C(OCO6)C6=C5)N3)=C2)=O)(=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Méndez-Luna D et, al. Preclinical approach of two novel tetrahydroquinoline derivatives targeting GPER and Bcl-2 for anti-glioblastoma therapy. Sci Rep. 2025 May 21;15(1):17710. [Content Brief]

GPER/Bcl-2-IN-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPER/Bcl-2-IN-1Estrogen Receptor/ERRBcl-2 FamilyGBMPrimary brain tumorDual-inhibitionInhibitorinhibitorinhibit

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