SDH-IN-25 

SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC₅₀ = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control^[1].

SDH-IN-25 (Compound 7IIj) (0-20 mg/L) demonstrates excellent and broad-spectrum fungicidal effects against 8 phytopathogenic strains including R. solani (EC₅₀ = 0.179 mg/L), P. piricola (EC₅₀ = 0.301 mg/L), S. sclerotiorum (EC₅₀ = 3.47 mg/L), V. mali (EC₅₀ = 0.789 mg/L), F. graminearum (EC₅₀ = 6.29 mg/L), B. cinerea (EC₅₀ = 0.647 mg/L), P. capsici (EC₅₀ = 5.78 mg/L), and G. graminis (EC₅₀ = 0.549 mg/L)^[1].
SDH-IN-25 (5-20 mg/L, 1-9 h) results in the inhibition of respiratory metabolism of R. solani^[1].
SDH-IN-25 (0-20 mg/L, 2 d) exhibits excellent R. solani SDH inhibitory activity with an IC₅₀ value of 4.82 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SDH-IN-25 (Compound 7IIj) (200 mg/L, dipped in a solution, 24 h) displays a notable protective effect in apple twigs infected with V. mali, with a control efficacy of 69.7%^[1].
SDH-IN-25 (100 mg/L, 10 min) shows a significant preventive effect on detached rice leaves with R. solani (control efficacy of 88.7%) and on rice plants with R. solani (control efficacy of 69.8%), where safety for rice is verified^[1].
SDH-IN-25 (1 mg/L, 72 h) results in abnormal mycelial growth, characterized by desiccated, collapsed, and shriveled surfaces of R. solani hyphae^[1].
SDH-IN-25 (0.179 mg/L) leads to increased ROS level and disruption of MMP in hyphae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

486.14

C₁₉H₁₅BrCl₂N₂O₄

3052432-15-9

ClC1=CC(Cl)=C(OCC(NNC2=CC=C(Br)C=C2)=O)C(C3OC(C(C3)=C)=O)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang FY, Xu D, He HW, Lin GT, Zhou H, Liu X, Xu G. Discovery of α-Methylene-γ-Butyrolactone Derivatives with Hydrazide Moieties as Novel Fungicidal Agents. J Agric Food Chem. 2025 Apr 23;73(16):9521-9532.  [Content Brief]