IMP-3 Antibody (YA4918)

IMP-3 Antibody (YA4918) is a mouse-derived and non-conjugated monoclonal antibody, targeting to IMP-3. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

IGF2BP3 is an RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This 'caging' of transcripts into mRNPs enables mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational machinery while shielding them from endonuclease attacks or microRNA-mediated degradation. IGF2BP3 preferentially binds N6-methyladenosine (m6A)-containing mRNAs, enhancing their stability. It binds the 3'-UTR of CD44 mRNA, stabilizing it and promoting cell adhesion and invadopodia formation in cancer cells. Additionally, IGF2BP3 binds beta-actin/ACTB and MYC transcripts, increasing MYC mRNA stability by interacting with its coding region instability determinant (CRD), with binding further enhanced by m6A modification of the CRD. by similar: It also binds the 5'-UTR of insulin-like growth factor 2 (IGF2) mRNA.

O00425

Predicted band size: 64 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human IMP-3 expressed in E. Coli.