2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-A/B-IN-5

MAO-A/B-IN-5 is an orally active MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM) inhibitor. MAO-A/B-IN-5 reverses Sodium nitroprusside (SNP) (HY-B0564)-induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM). MAO-A/B-IN-5 shows dose-dependent and time-dependent antidepressant-like efficacy in mice. MAO-A/B-IN-5 can be used for the study of depressive disorder.

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MAO-A/B-IN-5

MAO-A/B-IN-5 Chemical Structure

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MAO-A/B-IN-5 Related Antibodies

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Description

MAO-A/B-IN-5 is an orally active MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM) inhibitor. MAO-A/B-IN-5 reverses Sodium nitroprusside (SNP) (HY-B0564)-induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM). MAO-A/B-IN-5 shows dose-dependent and time-dependent antidepressant-like efficacy in mice. MAO-A/B-IN-5 can be used for the study of depressive disorder[1].

IC50 & Target[1]

MAO-A

73.88 μM (IC50)

MAO-B

91.08 μM (IC50)

In Vitro

MAO-A/B-IN-5 (Compound 3B) (25-200 μM) significantly inhibits cerebral MAO-A and MAO-B activities in mouse brain tissue, with IC50 values of 73.88 μM for MAO-A and 91.08 μM for MAO-B[1].
MAO-A/B-IN-5 (100-500 μM) reverses sodium nitroprusside (SNP)-induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-A/B-IN-5 Related Antibodies
In Vivo

MAO-A/B-IN-5 (Compound 3B) (0.5-5 mg/kg, i.g., once) exerts antidepressant-like effects in the TST of male Swiss mice[1].
MAO-A/B-IN-5 (50-300 mg/kg, , i.g., once, observed for 14 days) causes no mortality, no obvious toxicity signs, and no significant changes in food/water intake, body weight, or organ oxidative damage in female Swiss mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Swiss mice (25-30 g)[1]
Dosage: 0.5, 1, 2.5, 5 mg/kg
Administration: i.g., once
Result: Demonstrated dose-dependent antidepressant-like activity in male Swiss mice (30 min post-intragastric administration), with significant effects at doses of 1, 2.5, and 5 mg/kg.
Increased latency to immobility and reduced total immobility time in TST.
Molecular Weight

461.25

Formula

C21H20BrNOSe
SMILES

CC1=CC=C(C(C[N+]2=CC=CC=C2C[Se]C3=CC=CC=C3)=O)C=C1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-A/B-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-A/B-IN-5Monoamine OxidaseMAOMAO-A/Bdepressive disordercarbonylationlipid peroxidationInhibitorinhibitorinhibit

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