Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)

Name: Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)
Brand: MedChemExpress
SKU: HY-P990794
Rating: 4.5 (1 reviews)

Cat. No.: HY-P990794 Purity: 95.00%: Data Sheet
COA

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Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 antibody inhibitor, targeting to TNF-alpha/TNFSF2. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes of TNF-alpha. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) can be used for the researches of cancer, infection and immunology, such as dengue virus and B16K1 tumor.

For research use only. We do not sell to patients.

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) Featured Recommendations:

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View All Isoforms

TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG1

Recommend Isotype Controls

Rat IgG1 kappa, Isotype Control

IC₅₀ & Target

TNF-alpha/TNFSF2

In Vitro

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes endotoxin-induced murine embryo fibroblasts TNF production^[3].
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (10-1000 ng/mL, 7 days) reduces the number of differentiated osteoclasts in RAW264.7 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (10 μg, i.v., a single dose) reduces pulmonary TNF-α levels and improves survival in Delta P80 virus-infected mice models^[1].
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (100 μg, i.p., at days 1, 2, 3) decreases dengue virus 2-induced lethality in mice born to zika virus-immune mothers^[2].
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) (10 mg/kg, i.p., at days 6, 10, 13, 16) inhibits tumor growth and overcomes resistance to anti-PD-1 in B16K1 tumor mice models^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Delta P80 virus-infected mice models^[1]
Dosage:	10 μg
Administration:	Intravenously injection, a single dose
Result:	Significantly reduced pulmonary TNF-α levels and improved survival.

Animal Model:	Mice born to Zika virus-immune mothers^[2]
Dosage:	100 μg
Administration:	Intraperitoneally injection, at days 1, 2, 3
Result:	Exhibited improved clinical scores, weight gain, and increased survival.

Animal Model:	B16K1 tumor mice models^[5]
Dosage:	10 mg/kg
Administration:	Intraperitoneally injection, at days 6, 10, 13, 16
Result:	Delayed the B16K1 tumor growth and animal death. Enhances anti-PD-1 response.

Gene ID

21926 [NCBI]

Accession

P06804

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (262 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Kobayashi M, et al. TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages. PLoS Pathog. 2024 Dec 9;20(12):e1012776. [Content Brief]

[2]. Fowler AM, T et al. Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice. Cell Host Microbe. 2018 Nov 14;24(5):743-750.e5. [Content Brief]

[3]. Havell EA, et al. Endotoxin-induced tumor necrosis factor alpha synthesis in murine embryo fibroblasts. Infect Immun. 1993 May;61(5):1630-5. [Content Brief]

[4]. Katsumata K, et al. Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis. Arthritis Res Ther. 2019 Dec 23;21(1):298. [Content Brief]

[5]. Bertrand F, et al. TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma. Nat Commun. 2017 Dec 22;8(1):2256. [Content Brief]

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)TNF ReceptorDengue VirusTumor Necrosis Factor ReceptorTNFRDENVTNF-alphaTNFSF2InfectionVirusDengue virusMurine embryo fibroblastsDelta P80Inhibitorinhibitorinhibit

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Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11)

Customer Review

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) Featured Recommendations:

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All TNF Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) Related Antibodies

Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) Related Classifications

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