2. TGF-beta/Smad
  3. TGF-β Receptor
  4. IN-1130 (Standard)

IN-1130 (Standard) is the analytical standard of IN-1130. This product is intended for research and analytical applications. IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis.

For research use only. We do not sell to patients.

IN-1130 (Standard) Chemical Structure

IN-1130 (Standard) Chemical Structure

CAS No. : 868612-83-3

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Description
Molecular Weight

420.47

Formula

C25H20N6O
CAS No.
SMILES

O=C(N)C1=CC=CC(CC2=NC(C3=NC(C)=CC=C3)=C(C4=CC=C5N=CC=NC5=C4)N2)=C1
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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IN-1130 (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IN-1130 (Standard)868612-83-3TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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