SHP2-IN-38 

SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC₅₀ values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4–11 cells proliferation in vitro with IC₅₀ of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish^[1].

SHP2-IN-38 (0-20 μM, 3days) shows a strong ability to inhibit cell proliferation of MV4-11 with an IC₅₀ value of 7.90 μM^[1].

SHP2-IN-38 (20 μM, 24 h) reduces the phosphorylation level of p-ERK in MV4-11 cells^[1].

SHP2-IN-38 (10-100 μM) exhibits two distinct absorption peaks at 320 nm and 360 nm, with 360 nm selected as the optimal excitation wavelength, and a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF^[1].

SHP2-IN-38 (20 μM, 16 h) has good fluorescence imaging in HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SHP2-IN-38 (1 h) has good fluorescence imaging in zebrafish^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

377.42

C₂₀H₁₅N₃O₃S

OC1=C(C(O)=O)C=C(C2=CN(N=C(/C=C/C3=CC=C(C)C=C3)S4)C4=N2)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang C, et al. Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors. Bioorg Chem. 2025 May 27;163:108635.  [Content Brief]