1. MAPK/ERK Pathway Stem Cell/Wnt Protein Tyrosine Kinase/RTK Others
  2. ERK SHP2 Fluorescent Dye
  3. SHP2-IN-38

SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC50 values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4–11 cells proliferation in vitro with IC50 of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish[1].

For research use only. We do not sell to patients.

SHP2-IN-38 Chemical Structure

SHP2-IN-38 Chemical Structure

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Description

SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC50 values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4–11 cells proliferation in vitro with IC50 of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish[1].

In Vitro

SHP2-IN-38 (0-20 μM, 3days) shows a strong ability to inhibit cell proliferation of MV4-11 with an IC50 value of 7.90 μM[1].

SHP2-IN-38 (20 μM, 24 h) reduces the phosphorylation level of p-ERK in MV4-11 cells[1].

SHP2-IN-38 (10-100 μM) exhibits two distinct absorption peaks at 320 nm and 360 nm, with 360 nm selected as the optimal excitation wavelength, and a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF[1].

SHP2-IN-38 (20 μM, 16 h) has good fluorescence imaging in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SHP2-IN-38 (1 h) has good fluorescence imaging in zebrafish[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.42

Formula

C20H15N3O3S

SMILES

OC1=C(C(O)=O)C=C(C2=CN(N=C(/C=C/C3=CC=C(C)C=C3)S4)C4=N2)C=C1

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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SHP2-IN-38
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HY-174322
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