2. Cell Cycle/DNA Damage
  3. Wee1
  4. WEE1-IN-10

WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC50 of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1.

For research use only. We do not sell to patients.

WEE1-IN-10

WEE1-IN-10 Chemical Structure

CAS No. : 2226938-19-6

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Based on 1 publication(s) in Google Scholar

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Description

WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC50 of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1[1].

Molecular Weight

565.50

Formula

C28H30Cl2N8O
CAS No.
Appearance

Solid

Color

light yellow

SMILES

CC1=C(N2C[C@H](C)N(C)[C@H](C)C2)C=CC(NC3=NC=C4C(N5C(N(C6=C(Cl)C=CC=C6Cl)C4=O)=NCC5)=N3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (88.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7683 mL 8.8417 mL 17.6835 mL
5 mM 0.3537 mL 1.7683 mL 3.5367 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7683 mL 8.8417 mL 17.6835 mL 44.2087 mL
5 mM 0.3537 mL 1.7683 mL 3.5367 mL 8.8417 mL
10 mM 0.1768 mL 0.8842 mL 1.7683 mL 4.4209 mL
15 mM 0.1179 mL 0.5894 mL 1.1789 mL 2.9472 mL
20 mM 0.0884 mL 0.4421 mL 0.8842 mL 2.2104 mL
25 mM 0.0707 mL 0.3537 mL 0.7073 mL 1.7683 mL
30 mM 0.0589 mL 0.2947 mL 0.5894 mL 1.4736 mL
40 mM 0.0442 mL 0.2210 mL 0.4421 mL 1.1052 mL
50 mM 0.0354 mL 0.1768 mL 0.3537 mL 0.8842 mL
60 mM 0.0295 mL 0.1474 mL 0.2947 mL 0.7368 mL
80 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5526 mL
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WEE1-IN-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WEE1-IN-102226938-19-6Wee1lovo cellInhibitorinhibitorinhibit

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