2. Cell Cycle/DNA Damage Epigenetics Apoptosis Immunology/Inflammation
  3. DNA/RNA Synthesis MicroRNA Apoptosis Pyroptosis
  4. TRBP-IN-1

TRBP-IN-1 (Compound 13j) is an orally active TAR RNA binding protein 2 (TRBP) inhibitor (IC50: 12.72 μM). TRBP-IN-1 has significant anti-hepatocellular carcinoma (HCC) activity and can inhibit the proliferation and metastasis of HCC cells (HCCLM3 cells (IC50: 18.96 μM); SK-Hep-1 cells (IC50: 18.96 μM)). TRBP-IN-1 regulates miRNA biogenesis and inhibits oncogenic miRNA expression by targeting TRBP. TRBP-IN-1 induces apoptosis and pyroptosis in HCC cells by inhibiting the level of miRNA. TRBP-IN-1 can be used for targeted therapy research of HCC.

For research use only. We do not sell to patients.

TRBP-IN-1 Chemical Structure

TRBP-IN-1 Chemical Structure

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Description

TRBP-IN-1 (Compound 13j) is an orally active TAR RNA binding protein 2 (TRBP) inhibitor (IC50: 12.72 μM). TRBP-IN-1 has significant anti-hepatocellular carcinoma (HCC) activity and can inhibit the proliferation and metastasis of HCC cells (HCCLM3 cells (IC50: 18.96 μM); SK-Hep-1 cells (IC50: 18.96 μM)). TRBP-IN-1 regulates miRNA biogenesis and inhibits oncogenic miRNA expression by targeting TRBP. TRBP-IN-1 induces apoptosis and pyroptosis in HCC cells by inhibiting the level of miRNA. TRBP-IN-1 can be used for targeted therapy research of HCC[1].

Molecular Weight

520.52

Formula

C25H23F3N2O5S
SMILES

COC(C1=C(C(OC)=C(C(OC)=C1)OC)C2=CC=C(C=C2)NC(NC3=CC=CC(C(F)(F)F)=C3)=S)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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TRBP-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRBP-IN-1DNA/RNA SynthesisMicroRNAApoptosisPyroptosismiRNAHCCTRBPHCCLM3 cellsSK-Hep-1 cellsSCID miceInhibitorinhibitorinhibit

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