2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase
  4. SRD5A1-IN-2

SRD5A1-IN-2 is a inhibitor of steroid 5α-reductase type-1 (SRD5A1), with an IC50 of 8.5 μM. SRD5A1-IN-2 downregulates SRD5A1 protein expression in HaCaT cells. SRD5A1-IN-2 reduces dihydrotestosterone (DHT) production in HaCaT cells. SRD5A1-IN-2 can be used for the study of androgen-related conditions such as androgenetic alopecia (AGA).

For research use only. We do not sell to patients.

SRD5A1-IN-2

SRD5A1-IN-2 Chemical Structure

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SRD5A1-IN-2 Related Antibodies

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Description

SRD5A1-IN-2 is a inhibitor of steroid 5α-reductase type-1 (SRD5A1), with an IC50 of 8.5 μM. SRD5A1-IN-2 downregulates SRD5A1 protein expression in HaCaT cells. SRD5A1-IN-2 reduces dihydrotestosterone (DHT) production in HaCaT cells. SRD5A1-IN-2 can be used for the study of androgen-related conditions such as androgenetic alopecia (AGA)[1].

IC50 & Target[1]

SRD5A1

8.5 μM (IC50)

In Vitro

SRD5A1-IN-2 (Compound 10a) shows cytotoxicity with a half-maximal lethal concentration (LC50) of 21.31 μM in HaCaT cells[1].
SRD5A1-IN-2 (10 μM, 24 h) inhibits steroid 5α-reductase type-1 (SRD5A1) activity with an IC50 of 8.5 μM and reduces dihydrotestosterone (DHT) production in HaCaT cells[1].
SRD5A1-IN-2 (2.5-15 μM, 24 h) significantly downregulates SRD5A1 protein expression in HaCaT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SRD5A1-IN-2 Related Antibodies

Cell Viability Assay[1]

Cell Line: HaCaT cells
Concentration: 2.5, 5, 10, 15 μM
Incubation Time: 24 h
Result: Downregulated SRD5A1 protein expression in HaCaT cells.
Molecular Weight

406.28

Formula

C18H12F6O4
SMILES

COC1=C(C=CC(/C=C/C(OC2=C(C=CC(C(F)(F)F)=C2)C(F)(F)F)=O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SRD5A1-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRD5A1-IN-25 alpha Reductase5α-reductaseandrogenetic alopeciaandrogensteroid 5α-reductase type-1Inhibitorinhibitorinhibit

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