2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Influenza Virus
  4. RNA polymerase-IN-4

RNA polymerase-IN-4 is a RNA polymerase inhibitor with an EC50 of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC50 = 3.76 nM), relatively low cytotoxicity (CC50 = 29.91 μM). RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection.

For research use only. We do not sell to patients.

RNA polymerase-IN-4

RNA polymerase-IN-4 Chemical Structure

CAS No. : 3040910-48-0

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RNA polymerase-IN-4 Related Antibodies

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Description

RNA polymerase-IN-4 is a RNA polymerase inhibitor with an EC50 of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC50 = 3.76 nM), relatively low cytotoxicity (CC50 = 29.91 μM). RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection[1].

In Vivo

RNA polymerase-IN-4 (Compound (S,S)-5a) (5-10 mg/kg, i.v., twice a day from day 2 post-infection) significantly alleviates weight loss and reduces lung tissue viral load in BALB/c mice infected with influenza A/WSN/33 (H1N1)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice infected with influenza A/WSN/33 (H1N1)[1]
Dosage: 5 and 10 mg/kg
Administration: Intravenously injection, twice a day from day 2 post-infection
Result: Alleviated weight loss and reduced lung tissue viral load.
Showed no obvious abnormal toxicity.
Molecular Weight

537.58

Formula

C28H25F2N3O4S
CAS No.
SMILES

FC1=C(F)C=CC2=C1CSC3=C(C=CC=C3)[C@H]2N4[C@@H](CC5(CCOCC5)C6)N6C(C(N4C=C7)=C(O)C7=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RNA polymerase-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RNA polymerase-IN-43040910-48-0DNA/RNA SynthesisInfluenza VirusInfluenzaRNA polymeraseinfectionA/WSN/33 (H1N1)virusInhibitorinhibitorinhibit

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