2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Apoptosis
  3. Carbonic Anhydrase CDK Apoptosis
  4. CAIX/CDK-2-IN-1

CAIX/CDK-2-IN-1 is a dual-acting inhibitor of carbonic anhydrase IX (CA IX) and cyclin-dependent kinase-2 (CDK-2) with IC50 values of 0.29 μM and 0.32 μM. The zein nanoparticls of CAIX/CDK-2-IN-1 can induce cancer cells apoptosis. CAIX/CDK-2-IN-1 can be used for the research of cancer, such as ling cancer.

For research use only. We do not sell to patients.

CAIX/CDK-2-IN-1

CAIX/CDK-2-IN-1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CAIX/CDK-2-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Carbonic Anhydrase Isoform Specific Products:

View All Isoforms
CA CA I CA Ⅱ CA IX CA XII

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CAIX/CDK-2-IN-1 is a dual-acting inhibitor of carbonic anhydrase IX (CA IX) and cyclin-dependent kinase-2 (CDK-2) with IC50 values of 0.29 μM and 0.32 μM. The zein nanoparticls of CAIX/CDK-2-IN-1 can induce cancer cells apoptosis. CAIX/CDK-2-IN-1 can be used for the research of cancer, such as ling cancer[1].

IC50 & Target[1]

CA IX

0.29 μM (IC50)

CDK2

0.32 μM (IC50)

In Vitro

CAIX/CDK-2-IN-1 (Compound 5c) (Zein NPs) (10 μM) shows cell growth inhibition rate (GI%) of 94.8% in A549 cells, while its free base only has GI% of 3%[1].
CAIX/CDK-2-IN-1 (Zein NPs) (48 h) induce apoptosis, upregulates the expression of P53, Bax, PUMA and Caspase-3/8/9 genes and downregulates Bcl-2 in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAIX/CDK-2-IN-1 Related Antibodies
In Vivo

CAIX/CDK-2-IN-1 (Compound 5c) (Zein NPs) (6 mg/kg, intranasal administration, daily from week 17 to 20) shows anti-tumor activity in BALB/c mice with Urethane (HY-B1207)-induced lung cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with Urethane (HY-B1207)-induced lung cancer[1]
Dosage: 6 mg/kg (Zein NPs)
Administration: Intranasally administration, daily from week 17 to 20
Result: Reduced the lung index (relative lung weight from 2.91 to 1.35) .
Decreased lung weight (from 567.4±26.7 mg to 298.6±16.4 mg).
Inhibited the protein expression of hCA IX, hCA XII and CDK-2 by 45%, 58% and 46% respectively.
Improved the 20-week survival rate of mice to 40%.
Molecular Weight

584.09

Formula

C25H18ClN5O4S3
SMILES

ClC1=CC=C(C2=NC(N=C(SCC(NC3=CC=C(S(=O)(N)=O)C=C3)=O)NC4=O)=C4C(C5=CC=CS5)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CAIX/CDK-2-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAIX/CDK-2-IN-1Carbonic AnhydraseCDKApoptosisCarbonate dehydrataseCyclin dependent kinasecarbonic anhydrase IXhCA IXcyclin-dependent kinase-2CDK-2A549P53BaxPUMAcancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CAIX/CDK-2-IN-1
Cat. No.:
HY-179022
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.