2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. TrxR Reactive Oxygen Species Apoptosis
  4. TrxR-IN-8

TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC50: 10.2 μM). TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.

For research use only. We do not sell to patients.

TrxR-IN-8 Chemical Structure

TrxR-IN-8 Chemical Structure

CAS No. : 2857180-28-8

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TrxR-IN-8 Related Antibodies

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Description

TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC50: 10.2 μM). TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells[1].

Molecular Weight

381.21

Formula

C16H16INO2
CAS No.
SMILES

COC1=CC(OC)=CC2=C1C3=C(C=[N+]2C)C=CC=C3.[I-]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TrxR-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrxR-IN-82857180-28-8TrxRReactive Oxygen SpeciesApoptosisThioredoxin ReductaseapoptosisHeLa cellsHepG2 cellsA549 cellsBALB/c nude miceNSCLCInhibitorinhibitorinhibit

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