Telomerase-IN-8 

Telomerase-IN-8 is an orally active telomerase inhibitor, with an IC₅₀ value of 0.98 μM. Telomerase-IN-8 exhibits potent antiproliferative activity against multiple tumor cell lines, including PC3, Bcap-37, MGC-803 and HepG2. Telomerase-IN-8 demonstrates potent antitumor efficacy in S180 sarcoma or HepG2 hepatoma xenograft mice. Telomerase-IN-8 can be used for the study of telomerase-targeted anticancer^[1].

Telomerase-IN-8 (Compound 13i) (48 h) shows potent antiproliferative activity against PC3, Bcap-37, MGC-803, and HepG2 tumor cells, with IC₅₀ values of 4.87 μM, 3.37 μM, 2.96 μM, and 2.45 μM, respectively^[1].
Telomerase-IN-8 (48 h) exhibits low toxicity to human normal GES-1 and L-02 cells, with IC₅₀ values of 1.64 mM and 1.62 mM, respectively^[1].
Telomerase-IN-8 displays potent inhibitory activity against human telomerase modified TRAP assay in MGC-803 cell extracts, with an IC₅₀ value of 0.98 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Telomerase-IN-8 (Compound 13i) (60 mg/kg, p.o., once daily, 10 consecutive days) demonstrates potent antitumor efficacy in S180 sarcoma or HepG2 hepatoma xenograft Kunming mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

459.58

C₂₈H₃₃N₃O₃

1884341-01-8

O=C1OC2=C(C=C1C3=NN(C(C3)C4=CC=CC=C4)C(CN(CCCC)CCCC)=O)C=CC=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang Y, et al. Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo. Eur J Med Chem. 2016 Apr 13;112:231-251.  [Content Brief]