2. Metabolic Enzyme/Protease
  3. IMPDH
  4. IMPDH-IN-4

IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers.

For research use only. We do not sell to patients.

IMPDH-IN-4

IMPDH-IN-4 Chemical Structure

CAS No. : 2427862-70-0

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Based on 1 publication(s) in Google Scholar

IMPDH-IN-4 Related Antibodies

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Description

IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers[1].

In Vitro

IMPDH-IN-4 (Compound 9) has no significant inhibition of NAD synthesis (IC50 = 48 μM), does not inhibit NAMPT activity and NMN level in S462 cells[1].
IMPDH-IN-4 has toxic to S462 cells (IC50 = 1.20 μM) and Cas9-expressing HCT116 cells (IC50 = 20.8 nM)[1].
IMPDH-IN-4 (30 days) depends on NAMPT and NMNAT1 to accomplish activity in knock out NMNAT1 in both HCT116 and S462 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IMPDH-IN-4 Related Antibodies
Molecular Weight

204.25

Formula

C10H8N2OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=CS1)C2=CN=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (24.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8960 mL 24.4798 mL 48.9596 mL
5 mM 0.9792 mL 4.8960 mL 9.7919 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8960 mL 24.4798 mL 48.9596 mL 122.3990 mL
5 mM 0.9792 mL 4.8960 mL 9.7919 mL 24.4798 mL
10 mM 0.4896 mL 2.4480 mL 4.8960 mL 12.2399 mL
15 mM 0.3264 mL 1.6320 mL 3.2640 mL 8.1599 mL
20 mM 0.2448 mL 1.2240 mL 2.4480 mL 6.1200 mL
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IMPDH-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMPDH-IN-42427862-70-0IMPDHInosine-5’-monophosphate dehydrogenaseN-Pyridinylthiophene carboxamidS462 cellsHCT116 cellsInhibitorinhibitorinhibit

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