CYP51-IN-27 

CYP51-IN-27 is a sterol 14α-demethylase CYP51 inhibitor with an IC₅₀ of 0.3434 μg/mL. CYP51-IN-27 exhibits antifungal activity and inhibits the production of fungal ergosterol. CYP51-IN-27 can be used for the research of infection, such as rice sheath blight^[1].

CYP51-IN-27 (Compound 4r) demonstrates excellent efficacy against R. solani, with EC₅₀ values of 0.33 μg/mL^[1].
CYP51-IN-27 (20 μg/mL, 4 days) causes mycelium became desiccated, twisted, and irregular, with a rough, wrinkled, and collapsed surface, accompanied by the presence of some fragments in R. solani^[1].
CYP51-IN-27 (200 μg/mL, 7-28 days) exhibits good protective and curative activities against R. solani on rice plants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.35

C₂₂H₁₂F₆N₄

N#CNC(N=C/12)=NC(C3=CC(F)=C(F)C(F)=C3)=C2CCCC1=C/C4=CC(F)=C(F)C(F)=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Deng ZQ, et al. Antifungal Activity of Novel 5,6,7,8-Tetrahydroquinazolin Derivatives against Plant Pathogenic Fungi by Targeting Sterol 14α-Demethylase (CYP51) and the Application on Rice. J Agric Food Chem. 2025 Sep 24;73(38):24392-24403.  [Content Brief]