2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis Bcl-2 Family Caspase
  4. STAT3-IN-44

STAT3-IN-44 is a potent STAT3 inhibitor with IC50s of 1.84 (C6 cells) and 4.81 μM (A549 cells). STAT3-IN-44 inhibits STAT3 phosphorylation, downregulates Bcl-2, and upregulates Caspase-3 to promote late-stage apoptosis. STAT3-IN-44 significantly suppresses tumor cell proliferation and migration. STAT3-IN-44 can be used for the study of cancers such as glioma and lung cancer.

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STAT3-IN-44 Chemical Structure

STAT3-IN-44 Chemical Structure

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STAT3-IN-44 Related Antibodies

Top Publications Citing Use of Products

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STAT3 STAT5 STAT6 STAT1

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

STAT3-IN-44 is a potent STAT3 inhibitor with IC50s of 1.84 (C6 cells) and 4.81 μM (A549 cells). STAT3-IN-44 inhibits STAT3 phosphorylation, downregulates Bcl-2, and upregulates Caspase-3 to promote late-stage apoptosis. STAT3-IN-44 significantly suppresses tumor cell proliferation and migration. STAT3-IN-44 can be used for the study of cancers such as glioma and lung cancer[1].

IC50 & Target[1]

Caspase 3

 

Bcl-2

 

STAT3

 

In Vitro

STAT3-IN-44 (Compound 18q) (10 μM, 24-48 h) significantly induces the proportion of apoptotic C6 cells through the STAT3-Bcl-2/Caspase-3 pathway[1].
STAT3-IN-44 (2.5-10 μM, 10 days) almost completely inhibits colony formation at a concentration of 10 μM in C6 cells[1].
STAT3-IN-44 (10 μM, 24 h) significantly inhibits the migration of C6 cells[1].
STAT3-IN-44 (50 μM, 37-70°C) significantly enhances the thermal stability of STAT3 in C6 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-44 Related Antibodies

Apoptosis Analysis[1]

Cell Line: C6 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Revealed distinct apoptotic features, including chromatin condensation and apoptotic body formation.
Significantly increased the number of apoptotic cells and late apoptotic cells.

Western Blot Analysis[1]

Cell Line: C6 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 48 h
Result: Reduced the phosphorylation of STAT3, while the total STAT3 was almost unchanged.
Downregulated the expression of Bcl-2 and upregulated cleaved Caspase-3.

Cell Migration Assay [1]

Cell Line: C6 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Significantly inhibited cell migration.
Molecular Weight

546.06

Formula

C31H32ClN3O4
SMILES

COC1=CC(/C=C/C2=CC=C(C=C2)OCC(N3CCN(CC3)CC4=CNC5=C4C=C(C=C5)Cl)=O)=CC(OC)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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STAT3-IN-44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-44STATApoptosisBcl-2 FamilyCaspasePterostilbene-indole hybridsAnticancerMechanism of actionC6 cellsA549 cellsInhibitorinhibitorinhibit

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