2. Immunology/Inflammation Apoptosis
  3. Salt-inducible Kinase (SIK) Interleukin Related TNF Receptor
  4. SIK2-IN-4

SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC50s 0.143 and 0.076 μM, respectively). SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB)-dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC50: 0.11 µM), IL-12/23 p40 (IC50: 0.25 µM), and IL-23 (IC50: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases.

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SIK2-IN-4 Chemical Structure

SIK2-IN-4 Chemical Structure

CAS No. : 2810810-00-3

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SIK2-IN-4 Related Antibodies

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SIK1 SIK2 SIK3

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC50s 0.143 and 0.076 μM, respectively). SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB)-dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC50: 0.11 µM), IL-12/23 p40 (IC50: 0.25 µM), and IL-23 (IC50: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases[1].

IC50 & Target[1]

SIK1

0.143 μM (IC50)

SIK2

0.076 μM (IC50)

IL-23

0.47 μM (IC50)

Molecular Weight

388.42

Formula

C21H20N6O2
CAS No.
SMILES

N#CC1=CC(C2=CC3=CC(NC(C4CC4)=O)=NN3C=C2)=C(OC5CN(C5)C)C=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SIK2-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIK2-IN-42810810-00-3Salt-inducible Kinase (SIK)Interleukin RelatedTNF ReceptorILTumor Necrosis Factor ReceptorTNFRSIKAMPKIBDCDIL-10TNFimmunological disordersInhibitorinhibitorinhibit

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