2. Cytoskeleton Anti-infection Membrane Transporter/Ion Channel
  3. Integrin Orthopoxvirus Potassium Channel
  4. ITGB3-IN-1

ITGB3-IN-1 is an orally active integrin subunit beta 3 ITGB3 inhibitor with a Kd of 7.26 μM. ITGB3-IN-1 exhibits potent anti-orthopoxvirus effects with an EC50 for vaccinia virus (VACV) of 1.82 μM. ITGB3-IN-1 inhibits hERG with an IC50 of 1.13 μM. ITGB3-IN-1 can be used for the study of orthopoxvirus.

For research use only. We do not sell to patients.

ITGB3-IN-1

ITGB3-IN-1 Chemical Structure

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ITGB3-IN-1 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

ITGB3-IN-1 is an orally active integrin subunit beta 3 ITGB3 inhibitor with a Kd of 7.26 μM. ITGB3-IN-1 exhibits potent anti-orthopoxvirus effects with an EC50 for vaccinia virus (VACV) of 1.82 μM. ITGB3-IN-1 inhibits hERG with an IC50 of 1.13 μM. ITGB3-IN-1 can be used for the study of orthopoxvirus[1].

In Vitro

ITGB3-IN-1 (Compound 6) has low cytotoxicity (CC50 = 400 μM) and high therapeutic index (219.78) against VACV in Vero cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ITGB3-IN-1 Related Antibodies
Parmacokinetics[1]
Species Dose Route Indicator value
Mice 90 mg/kg p.o. Tmax 0.33 h
Mice 90 mg/kg p.o. Cmax 25800 ng/mL
Mice 90 mg/kg p.o. AUC0-t 40920 ng·h/mL
Mice 90 mg/kg p.o. AUC0-∞ 41725 ng·h/mL
Mice 90 mg/kg p.o. T1/2 2.93 h
In Vivo

ITGB3-IN-1 (Compound 6) (45-90 mg/kg, i.g., once a day for five doses) exhibits potent anti-VACV activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: VACV infection model established in female, 4-week-old nude mice[1]
Dosage: 45 and 90 mg/kg
Administration: Gavage administration (i.g.), once a day for a total of five doses
Result: Reached the inhibition rate by 88.6% at a dose of 90 mg/kg.
Effectively protected the liver and spleen of mice from viral-induced pathological damage.
Observed no significant toxicity and the mice's weight remained stable.
Molecular Weight

397.46

Formula

C23H27NO5
SMILES

COC1=CC=C(C=C1OC)/C=C/C(NC2=C(C=CC=C2)C(OCCC(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ITGB3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITGB3-IN-1IntegrinOrthopoxvirusPotassium ChannelKcsAAnti-orthopoxvirusDual-view deep learningIntegrin beta 3Photoaffinity probeTarget identificationInhibitorinhibitorinhibit

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