2. Metabolic Enzyme/Protease Apoptosis
  3. Farnesyl Transferase Apoptosis
  4. SQS-IN-1

SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer.

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SQS-IN-1

SQS-IN-1 Chemical Structure

CAS No. : 2306302-57-6

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SQS-IN-1 Related Antibodies

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Description

SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer[1].

In Vitro

SQS-IN-1 (Compound 2) (0.1 nM-100 μM, 24-72 h) inhibits various lung cancer cell lines proliferation including LLCOVA cells, NSCLC cell lines (H1299 and H358) and B16 melanoma cells and with TC50s of 3.21 nM, 1.6 μM, 0.55 μM and 0.21 μM at 72 h[1].
SQS-IN-1 (10 and 0.1 μM, 24 h) induces G0/G1 phase arrest in A549 cells and arrested DNA replication in LLC-OVA cells[1].
SQS-IN-1 (0.1 μM, 24 h) induces LLC-OVA cells apoptosis and effectively inhibits the metastasis ability of cancer cells[1].
SQS-IN-1 (0-10 μM) causes mitochondrial hyperpolarization in a dose-dependent manner in LLC-OVA cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SQS-IN-1 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: A549 and LLC-OVA cells
Concentration: 10 μM (A549) and 0.1 μM (LLC-OVA)
Incubation Time: 24 h
Result: Significantly reduced the proportion of cells in the S phase and the G2 phase, resulting in the accumulation of cells in the G0/G1 phase in A549 cells.
Inhibited DNA replication and the cell cycle progression in LLC-OVA.

Apoptosis Analysis[1]

Cell Line: LLC-OVA cells
Concentration: 0.1 μM
Incubation Time: 24 h
Result: Significantly increased the percentage of cells in the early apoptotic stage.

Cell Migration Assay [1]

Cell Line: LLC-OVA cells
Concentration: 0.1 μM
Incubation Time: 24 h
Result: Reduced the wound closure rate of LLC-OVA cells by approximately 23%.

Cell Invasion Assay[1]

Cell Line: LLC-OVA cells
Concentration: 0.1 μM
Incubation Time: 24 h
Result: Reduced the invasive ability of LLC-OVA cells by 25%.
Molecular Weight

503.39

Formula

C24H27BrN2O5
CAS No.
SMILES

CN1CCOC(C2=CC=C(C3=CC=C(C=CC=C4)C4=C3)C=C2)(OCCCO[N+]([O-])=O)C1.Br
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SQS-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SQS-IN-12306302-57-6Farnesyl TransferaseApoptosisFtaseSqualene Synthase (SQS)inhibitorscholesterollung cancerInhibitorinhibitorinhibit

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