2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. NADPH Oxidase Reactive Oxygen Species (ROS)
  4. NOX5-IN-2

NOX5-IN-2 (Compound 17) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC50s of 0.70  μM. NOX5-IN-2 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC50: 1.8  μM). NOX5-IN-2 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation.

For research use only. We do not sell to patients.

NOX5-IN-2 Chemical Structure

NOX5-IN-2 Chemical Structure

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NOX5-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All NADPH Oxidase Isoform Specific Products:

View All Isoforms
NOX1 NOX2 NOX4 NOX5 DUOX1

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Description

NOX5-IN-2 (Compound 17) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC50s of 0.70  μM. NOX5-IN-2 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC50: 1.8  μM). NOX5-IN-2 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation[1].

IC50 & Target[1]

NOX5

0.70 μM (IC50)

NOX1

>100 μM (IC50)

NOX2

>100 μM (IC50)

NOX4

>100 μM (IC50)

DUOX1

>15 μM (IC50)

Molecular Weight

394.84

Formula

C18H11ClN6OS
SMILES

ClC1=CC=C2N=C(OC2=C1)SC3=C4C(N(N=N4)CC5=CC=CC=C5)=NC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NOX5-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOX5-IN-2NADPH OxidaseReactive Oxygen Species (ROS)NOXInhibitorsNADPH oxidase 5NOX5ROSFreestyle293 cellsCardiovascularCancerNeuroinflammationInhibitorinhibitorinhibit

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