2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. GluN1/3A-IN-1

GluN1/3A-IN-1 (Compound GM-10) is a GluN1/GluN3A NMDA receptor inhibitor. GluN1/3A-IN-1 exhibits potent inhibitory activity against GluN1/GluN3A (IC50 0.98 µM). GluN1/3A-IN-1 exerts its inhibitory effect by targeting the pre-M1 region and forming hydrogen bond interactions with key residues. GluN1/3A-IN-1 can be used to study GluN1/GluN3A-related neurological diseases.

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GluN1/3A-IN-1 Chemical Structure

GluN1/3A-IN-1 Chemical Structure

CAS No. : 1147526-22-4

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GluN1/3A-IN-1 Related Antibodies

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Description

GluN1/3A-IN-1 (Compound GM-10) is a GluN1/GluN3A NMDA receptor inhibitor. GluN1/3A-IN-1 exhibits potent inhibitory activity against GluN1/GluN3A (IC50 0.98 µM). GluN1/3A-IN-1 exerts its inhibitory effect by targeting the pre-M1 region and forming hydrogen bond interactions with key residues. GluN1/3A-IN-1 can be used to study GluN1/GluN3A-related neurological diseases[1].

Molecular Weight

387.38

Formula

C23H17NO5
CAS No.
SMILES

O=C(C1=C(C=C(C=C1)O)O)OCC(C2C(C3=CC=CC=C3)=NC4=C2C=CC=C4)=O
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Room temperature in continental US; may vary elsewhere.
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GluN1/3A-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GluN1/3A-IN-11147526-22-4iGluRIonotropic glutamate receptorsNMDAGeminiMolLigand screeningpre-M1Inhibitorinhibitorinhibit

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