Mer/c-Met-IN-1 

Mer/c-Met-IN-1 is a potent Mer/c-met dual inhibitor with IC₅₀ values of 1 and 19 nM. Mer/c-Met-IN-1 can inhibit cancer cells proliferation, migration and induce apoptosis. Mer/c-Met-IN-1 can be used for the research of cancer, such as colon cancer^[1].

Mer/c-Met-IN-1 exhibits robust antiproliferative activity against HCT116, A2780, and PC-3 cancer cell lines with IC₅₀ values of 1.01 μM, 0.96 μM, and 3.42 μM respectively^[1].
Mer/c-Met-IN-1 shows favorable metabolic stability in human liver microsomes with a half-life (t_1/2) of 72.6 min and a clearance rate (CL) of 0.05 mL/min/mg^[1].
Mer/c-Met-IN-1 exhibits negligible inhibition on hERG potassium channels with an IC₅₀ value >40 μM^[1].
Mer/c-Met-IN-1 (0.4-3.2 μM, 48 h) induces dose-dependent apoptosis in HCT116 cells with an ED₅₀ of 1.368 pM^[1].
Mer/c-Met-IN-1 (0.8-20 μM, 24 h) significantly suppresses the migration of HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

675.75

C₃₈H₃₈FN₇O₄

3062159-91-2

CN1CCN(CC1)C2=CC(NC3=NC(OC4=CC=C(C=C4)NC(C5=CN(C=C(C5=O)C6=CC=C(C=C6)F)CC7CCCO7)=O)=CC=N3)=CC=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Duan L, et al. Design, synthesis, and biological evaluation of novel potent dual Mer/c-Met inhibitors based on structural optimization. Bioorg Med Chem Lett. 2025 Sep 20;130:130415.  [Content Brief]