2. Metabolic Enzyme/Protease
  3. 17β-HSD
  4. HSD17B13-IN-104

HSD17B13-IN-104 (Compound 32) is an orally active, highly potent and selective HSD17B13 inhibitor (IC50=2.5 nM). HSD17B13-IN-104 regulates hepatic lipid metabolism by inhibiting the SREBP-1c/FAS pathway. HSD17B13-IN-104 blocks HSD17B13 enzymatic activity to improve hepatic lipid accumulation. HSD17B13-IN-104 is promising for research of metabolic dysfunction-associated steatohepatitis.

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HSD17B13-IN-104

HSD17B13-IN-104 Chemical Structure

CAS No. : 3075100-76-1

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Description

HSD17B13-IN-104 (Compound 32) is an orally active, highly potent and selective HSD17B13 inhibitor (IC50=2.5 nM). HSD17B13-IN-104 regulates hepatic lipid metabolism by inhibiting the SREBP-1c/FAS pathway. HSD17B13-IN-104 blocks HSD17B13 enzymatic activity to improve hepatic lipid accumulation. HSD17B13-IN-104 is promising for research of metabolic dysfunction-associated steatohepatitis[1].

Molecular Weight

454.89

Formula

C21H18ClF3N2O2S
CAS No.
Appearance

Solid

Color

off-white

SMILES

O=C(C1=C(C)N=C(S1)C2=CC(F)=C(F)C(O)=C2F)N(C(C)C)CC3=CC=C(C=C3)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (109.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1983 mL 10.9917 mL 21.9833 mL
5 mM 0.4397 mL 2.1983 mL 4.3967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1983 mL 10.9917 mL 21.9833 mL 54.9583 mL
5 mM 0.4397 mL 2.1983 mL 4.3967 mL 10.9917 mL
10 mM 0.2198 mL 1.0992 mL 2.1983 mL 5.4958 mL
15 mM 0.1466 mL 0.7328 mL 1.4656 mL 3.6639 mL
20 mM 0.1099 mL 0.5496 mL 1.0992 mL 2.7479 mL
25 mM 0.0879 mL 0.4397 mL 0.8793 mL 2.1983 mL
30 mM 0.0733 mL 0.3664 mL 0.7328 mL 1.8319 mL
40 mM 0.0550 mL 0.2748 mL 0.5496 mL 1.3740 mL
50 mM 0.0440 mL 0.2198 mL 0.4397 mL 1.0992 mL
60 mM 0.0366 mL 0.1832 mL 0.3664 mL 0.9160 mL
80 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6870 mL
100 mM 0.0220 mL 0.1099 mL 0.2198 mL 0.5496 mL
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HSD17B13-IN-104 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSD17B13-IN-1043075100-76-117β-HSD17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenaseorally activeHSD17B13hepatic lipid accumulationInhibitorinhibitorinhibit

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