2. Cell Cycle/DNA Damage Cytoskeleton Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Microtubule/Tubulin Reactive Oxygen Species (ROS)
  4. Tubulin-IN-56

Tubulin-IN-56 is a tubulin inhibitor. Tubulin-IN-56 exerts cytotoxic effects against colon cancer cell lines (LS180, HCT116, SW620, LoVo). Tubulin-IN-56 downregulates βIII-tubulin and upregulates βIVa-tubulin in colon cancer cell lines. Tubulin-IN-56 inhibits cell invasiveness and elevates intracellular ROS levels in colon cancer cell lines. Tubulin-IN-56 can be used for the study of colon cancer.

For research use only. We do not sell to patients.

Tubulin-IN-56

Tubulin-IN-56 Chemical Structure

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Tubulin-IN-56 Related Antibodies

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Description

Tubulin-IN-56 is a tubulin inhibitor. Tubulin-IN-56 exerts cytotoxic effects against colon cancer cell lines (LS180, HCT116, SW620, LoVo). Tubulin-IN-56 downregulates βIII-tubulin and upregulates βIVa-tubulin in colon cancer cell lines. Tubulin-IN-56 inhibits cell invasiveness and elevates intracellular ROS levels in colon cancer cell lines. Tubulin-IN-56 can be used for the study of colon cancer[1].

In Vitro

Tubulin-IN-56 (Compound 1b) (12-48 h) increases the number of M-phase arrested cells and the apoptotic fraction in colorectal cancer cells (LS180, HCT116, SW620, LoVo) over time[1].
Tubulin-IN-56 shows antiproliferative activity against LS180, HCT116, SW620 and LoVo cells, with IC50 values of 279 nM, 102 nM, 132 nM and 45 nM, respectively[1].
Tubulin-IN-56 (3 μM, 80 min) alters microtubule polymerization rates in colon cancer cells (HCT116 and LoVo cells)[1].
Tubulin-IN-56 significantly downregulates βIII-tubulin and upregulates βIVa-tubulin in SW620, HCT116, and LoVo cells[1].
Tubulin-IN-56 (8 h) inhibits the invasiveness and reduces MMP-7 secretion in SW620, HCT116, and LoVo cells Tubulin-IN-56 decreases the cytosolic level of integrin-linked kinase (ILK) in LoVo cells[1].
Tubulin-IN-56 (1 μM, 4 h) elevates intracellular ROS levels in LS180, SW620, and LoVo cells[1].
Tubulin-IN-56 (72 h) reduces the growth of LoVo cell spheroids in 3D culture[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin-IN-56 Related Antibodies
Molecular Weight

1007.05

Formula

C51H55NO14Ru
SMILES

O=C(c1cccc1)N[C@@H](C2=CC=CC=C2)[C@@H](O)C(O[C@H]3C[C@]4(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]5(C)C([C@@](CO6)(OC(C)=O)[C@H]6C[C@@H]5O)[C@@H]4OC(C7=CC=CC=C7)=O)=O)=C3C)=O.[][Ru][].c8cccc8
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin-IN-56 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin-IN-56Microtubule/TubulinReactive Oxygen Species (ROS)TubulinLS180HCT116SW620LoVocolon cancerInhibitorinhibitorinhibit

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