2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Oxysterol-binding Protein-related Protein (ORP)

Oxysterol-binding Protein-related Protein (ORP)

Oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of LTPs known to harbor lipid ligands, such as cholesterol and phospholipids. ORPs act as a sensor or transporter of those lipid ligands at membrane contact sites (MCSs) where two different cellular membranes are closely apposed. In particular, a characteristic functional property of ORPs is their role as a lipid exchanger. ORPs mediate counter-directional transport of two different lipid ligands at MCSs. Several, but not all, ORPs transport their lipid ligand from the endoplasmic reticulum (ER) in exchange for phosphatidylinositol 4-phosphate (PI4P), the other ligand, on apposed membranes. This ORP-mediated lipid “countertransport” is driven by the concentration gradient of PI4P between membranes, which is generated by its kinases and phosphatases. Mounting evidence demonstrates that ORPs regulate a variety of cellular functions including, but not limited to, lipid transport, membrane/organelle trafficking, and signaling[1].

Oxysterol-binding Protein-related Protein (ORP) Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101213
    OSW-1
    		Antagonist 99.66%
    OSW-1, isolated from Ornithogalum caudatum, is a specific antagonist of ooxysterol binding protein (OSBP) and OSBP-related protein 4 (ORP4) with GI50s in the nanomolar range in human cancer lines.
    OSW-1
  • HY-143200
    OSBPL7-IN-1
    		Inhibitor 99.84%
    OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression.
    OSBPL7-IN-1
  • HY-178046
    OSBP ligand-Linker Conjugate 1
    		Inhibitor
    OSBP ligand-Linker Conjugate 1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for OSBP (HY-178035) and a PROTAC linker, which recruits E3 ligases. OSBP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034).
    OSBP ligand-Linker Conjugate 1
  • HY-178034
    PROTAC OSBP Degrader-1
    		Degrader
    PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells. Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker
    PROTAC OSBP Degrader-1
  • HY-178035
    OSBP ligand-1
    		Inhibitor
    OSBP ligand-1 (Compound 2) is an Oxysterol-binding protein (OSBP) inhibitor. OSBP ligand-1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034).
    OSBP ligand-1