2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Oxysterol-binding Protein-related Protein (ORP)
  5. Oxysterol-binding Protein-related Protein (ORP) Degrader

Oxysterol-binding Protein-related Protein (ORP) Degrader

Oxysterol-binding Protein-related Protein (ORP) Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-178034
    PROTAC OSBP Degrader-1
    		Degrader
    PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells. Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker