2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Oxysterol-binding Protein-related Protein (ORP)
  4. PROTAC OSBP Degrader-1

PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells. Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker

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PROTAC OSBP Degrader-1

PROTAC OSBP Degrader-1 Chemical Structure

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PROTAC OSBP Degrader-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells[1]. Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker

Molecular Weight

1017.17

Formula

C56H68N6O12
SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCCCCCN4N=NC(COC5=CC(/C=C/C6=CC7=C(C(OC)=C6)O[C@]8(C)CC[C@@H](O)C(C)(C)[C@@]8([H])C7)=CC(O)=C5C/C=C(C)\C)=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC OSBP Degrader-1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC OSBP Degrader-1PROTAC OSBP Degrader1PROTAC OSBP Degrader 1PROTACsOxysterol-binding Protein-related Protein (ORP)PROTACDegradationOxysterol-binding proteinOSBPTrans-Golgi networkAnticancerU-87 MG cellsA549 cellsMCF7 cellsHeLa cellsMDA-MB-231 cellsInhibitorinhibitorinhibit

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