2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1-IN-22

PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM.

For research use only. We do not sell to patients.

PD-1-IN-22 Chemical Structure

PD-1-IN-22 Chemical Structure

CAS No. : 2349372-98-9

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Based on 1 publication(s) in Google Scholar

PD-1-IN-22 Related Antibodies

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Description

PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM[1].

IC50 & Target

IC50: 92.3 nM (programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
92.3 nM
Compound: A22
Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 residues) expressed in HEK293 cells protein-protein interaction after 40 mins by APC-labeled anti-His antibody/
Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 residues) expressed in HEK293 cells protein-protein interaction after 40 mins by APC-labeled anti-His antibody/
[PMID: 32667799]
In Vitro

PD-1-IN-22 dose-dependently elevates IFN-γ secretion in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1-IN-22 Related Antibodies
Molecular Weight

459.50

Formula

C25H25N5O4
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

CC1=C(NC(C2=CC(CNCCO)=CN3C2=NN=C3)=O)C=CC=C1C4=CC5=C(OCCO5)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PD-1-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1-IN-222349372-98-9PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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Product Name:
PD-1-IN-22
Cat. No.:
HY-128605
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