ALK/p80 Antibody (YA4576)

Cat. No.: HY-P84879: Data Sheet User Guide for Antibodies
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ALK/p80 Antibody (YA4576) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ALK/p80. It can be applicated for WB, FC, ELISA assays, in the background of human.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
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Documentation

Description	ALK/p80 Antibody (YA4576) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ALK/p80. It can be applicated for WB, FC, ELISA assays, in the background of human.
Background	ALK is a neuronal receptor tyrosine kinase transiently expressed in specific nervous system regions, playing crucial roles in neurogenesis and differentiation. It also regulates energy homeostasis by controlling white adipose tissue lipolysis and sympathetic tone (By similarity). Activated by ALKAL2 (but not ALKAL1), it initiates intracellular signaling through MAPK pathway activation, phosphorylating targets like CBL, FRS2, IRS1, and SHC1. ALK may also be modulated by pleiotrophin (PTN) and midkine (MDK), which promote anti-apoptotic signaling and cell proliferation via MAPK/PI3K pathways. Additionally, ALK drives NF-κB activation through IRS1-AKT, essential for MDK-mediated autocrine growth and survival.
Gene ID	238 [NCBI]
SwissProt ID	Q9UM73
Synonyms	CD246; NBLST3
Molecular Weight	Predicted band size: 176 kDa; Observed band size: 180 kDa
Purity	affinity purified.
Conjugation	Non-conjugated
Product Categories	Primary Antibody; Mouse Monoclonal Antibody
Host	Mouse
Reactivity	Human
Dilution Ratio	WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000
Application	WB, FC, ELISA
Appearance	Liquid
Formulation	Supplied in PBS with 0.05% sodium azide
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG1
Immunogen	Purified recombinant fragment of human ALK/p80 (AA: 1359-1460) expressed in E. Coli.
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

ALK/p80 Antibody (YA4576) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ALK/p80 Antibody (YA4576)

Biological Activity

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ALK/p80 Antibody (YA4576) Related Classifications

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