2. Cell Cycle/DNA Damage
  3. p97
  4. p97-IN-1

p97-IN-1 is an orally active p97 inhibitor (IC50 = 26 nM). p97-IN-1 can significantly inhibit the proliferation of tumor cells. p97-IN-1 can be used for research on acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

p97-IN-1 Chemical Structure

p97-IN-1 Chemical Structure

CAS No. : 3007658-96-7

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p97-IN-1 Related Antibodies

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Description

p97-IN-1 is an orally active p97 inhibitor (IC50 = 26 nM). p97-IN-1 can significantly inhibit the proliferation of tumor cells. p97-IN-1 can be used for research on acute myeloid leukemia (AML)[1].

In Vitro

p97-IN-1 (Compound V12) (0-10 μM, 72 h) can inhibit the proliferation of various tumor cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p97-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: RPMI-8226, HCT-116, BXPC-3, SV620, ARP1, H929, MM-15, KMS-11, MV-4-11, Molm-13 and Molm-16 cells
Concentration: 0-10 μM
Incubation Time: 72 h
Result: Significantly inhibited the proliferation of various tumor cell lines, including RPMI-8226 (IC50 = 0.5 μM), HCT-116 (IC50 = 0.7 μM), BXPC-3 (IC50 = 1.4 μM), SV620 (IC50 = 2.3 μM), ARP1 (IC50 = 2.1 μM), H929 (IC50 = 0.7 μM), KMS-11 (IC50 = 2.1 μM), MV-4-11 (IC50 = 0.4 μM), Molm-13 (IC50 = 1.4 μM) and Molm-1 6(IC50 = 0.4 μM) cells.
In Vivo

p97-IN-1 (Compound V12) (100 mg/kg and 300 mg/kg; p.o.; once daily) significantly inhibits tumor growth and no significant toxicity is observed at high doses in the female BALB/c nude mice bearing Molm-13 xenograft tumor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice (6-8 weeks, 18-22 g) bearing 5×106 Molm-13 cells xenograft tumor[1]
Dosage: 100 mg/kg or 300 mg/kg
Administration: Oral administration (p.o.); once daily
Result: Significantly reduced tumor volume.
Did not significantly alter the weight of the mice.
Molecular Weight

442.51

Formula

C25H26N6O2
CAS No.
SMILES

CONC(C1=CC=CC2=C1C=C(N2C3=NC4=C(C(NCC5=CC=CC=C5)=N3)CCCN4)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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p97-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p97-IN-13007658-96-7p97VCPCdc48VCP/p97AMLinhibitorcancerLeukemiaInhibitorinhibit

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