2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation
  3. Indoleamine 2,3-Dioxygenase (IDO) TNF Receptor Interleukin Related
  4. IDO1-IN-27

IDO1-IN-27 (Compound I-1) is a Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor with an IC50 of 0.3951  μM for recombinant hIDO1. IDO1-IN-27 also inhibits hIDO1 expression in HeLa cells (EC50: 62 nM). IDO1-IN-27 effectively stimulates T cell proliferation by reducing the mRNA expression of pro-inflammatory factors (TNF-α, IL-6, and IL-1β) while concurrently inhibiting LLC cells growth.

For research use only. We do not sell to patients.

IDO1-IN-27

IDO1-IN-27 Chemical Structure

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IDO1-IN-27 Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

IDO1-IN-27 (Compound I-1) is a Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor with an IC50 of 0.3951  μM for recombinant hIDO1. IDO1-IN-27 also inhibits hIDO1 expression in HeLa cells (EC50: 62 nM). IDO1-IN-27 effectively stimulates T cell proliferation by reducing the mRNA expression of pro-inflammatory factors (TNF-α, IL-6, and IL-1β) while concurrently inhibiting LLC cells growth[1].

IC50 & Target[1]

hIDO1

0.3951 μM (IC50)

IL-6

 

IL-1β

 

Molecular Weight

435.25

Formula

C17H16BrFN6O2
SMILES

O/N=C(C1=NON=C1NCCNC2=CC=CC=C2)\NC3=CC=C(F)C(Br)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IDO1-IN-27 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-27Indoleamine 2,3-Dioxygenase (IDO)TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILInhibitorIDO1HeLa cellsLLC cellsTNF-αIL-6IL-1βinhibitorinhibit

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