2. Epigenetics Immunology/Inflammation
  3. Histone Demethylase PD-1/PD-L1
  4. LSD1-IN-42

LSD1-IN-42 (Compound 7ae) is an orally active LSD1 inhibitor that potently inhibits LSD1 activity (IC50 = 0.08 μM). LSD1-IN-42 downregulates PD-L1 expression and enhances T cell-mediated tumor killing effects. LSD1-IN-42 demonstrates significant anti-gastric cancer activity by inhibiting tumor cell invasion and migration.

For research use only. We do not sell to patients.

LSD1-IN-42 Chemical Structure

LSD1-IN-42 Chemical Structure

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LSD1-IN-42 Related Antibodies

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Description

LSD1-IN-42 (Compound 7ae) is an orally active LSD1 inhibitor that potently inhibits LSD1 activity (IC50 = 0.08 μM). LSD1-IN-42 downregulates PD-L1 expression and enhances T cell-mediated tumor killing effects. LSD1-IN-42 demonstrates significant anti-gastric cancer activity by inhibiting tumor cell invasion and migration[1].

IC50 & Target[1]

LSD1

0.08 μM (IC50)

Molecular Weight

505.93

Formula

C22H20ClN3O7S
SMILES

O=C1OCC(C1=C)C(O)C2=CN(C3=C2C=C(C=C3)Cl)S(=O)(C4=CC=C(C([N+]([O-])=O)=C4)N(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1-IN-42 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-42Histone DemethylasePD-1/PD-L1PD-1/Programmed death-ligand 1Gastric cancerT cellanticancer activityInhibitorinhibitorinhibit

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