PDIA1-IN-1 

PDIA1-IN-1 is a protein disulfide isomerase 1 (PDIA1) inhibitor. PDIA1-IN-1 can inhibit NLRP3 inflammasome assembly and activity, with an IC₅₀ value of 1 μM. PDIA1-IN-1 can reduce IL-1β secretion. PDIA1-IN-1 can be used for the researches of inflammation and neurological disease^[1].

PDIA1-IN-1 (Compound P11) inhibits ASC-GFP speck formation with an IC₅₀ value of 890 nM LPS (HY-D1056)-primed THP1 monocytes^[1].
PDIA1-IN-1 (1.25-2.5 μM, 2 h) dose-dependently engages PDIA1 in LPS-primed THP1 monocytes^[1].
PDIA1-IN-1 (5-10 μM, 1-16 h) reduces IL-1β secretion in LPS-primed THP1 monocytes^[1].
PDIA1-IN-1 (1 μM, 2 h) rescues viability in LPS-primed THP1 monocytes^[1].
PDIA1-IN-1 (10 μM, 1 h) decreases cell viability in LPS-primed THP1 monocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

569.67

C₂₉H₃₅N₃O₇S

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• [1]. Buasakdi C, et al. Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity. ACS Chem Biol. 2025 Aug 15;20(8):1892-1901.  [Content Brief]