2. Neuronal Signaling
  3. Amyloid-β
  4. TDP-43-IN-2

TDP-43-IN-2 (compound 17) is a TDP-43 inhibitor, and can be used for study of neurodegenerative disease.

For research use only. We do not sell to patients.

TDP-43-IN-2 Chemical Structure

TDP-43-IN-2 Chemical Structure

CAS No. : 3033951-93-5

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Based on 1 publication(s) in Google Scholar

TDP-43-IN-2 Related Antibodies

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Description

TDP-43-IN-2 (compound 17) is a TDP-43 inhibitor, and can be used for study of neurodegenerative disease[1].

Molecular Weight

439.51

Formula

C22H22FN5O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(CCN1C3=CC=CN=C3)N=C(C4=C(F)N=C(N5CCC(CC5)CO)C=C4)S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.38 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2753 mL 11.3763 mL 22.7526 mL
5 mM 0.4551 mL 2.2753 mL 4.5505 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2753 mL 11.3763 mL 22.7526 mL 56.8815 mL
5 mM 0.4551 mL 2.2753 mL 4.5505 mL 11.3763 mL
10 mM 0.2275 mL 1.1376 mL 2.2753 mL 5.6882 mL
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TDP-43-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDP-43-IN-23033951-93-5Amyloid-ββ-amyloid peptideAβAbetamyotrophic lateral sclerosisAlzheimer’s diseaseFrontotemporal dementiaInhibitorinhibitorinhibit

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