SDH-IN-32 

SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection^[1].

SDH-IN-32 (Compound A2) exhibits excellent antifungal activity against Rhizoctonia solani, Sclerotinia sclerotiorum, Valsa mali, Botrytis cinerea, Gibberella zeae, and Physalospora piricola, with EC₅₀ values of 0.133, 0.258, 0.428, 0.519, 1.29, and 1.51 μg/mL, respectively^[1].
SDH-IN-32 (200 μg/mL) shows protective efficacies of 76.1 against rice sheath blight, 64.5% against B. cinerea on tomato fruits and 67.7% against V. mali on apple fruits^[1].
SDH-IN-32 (0.133 μg/mL) destroys the cell membrane structure, increases the permeability of the cell membrane and decreases the MMP in R. solani^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

320.36

C₁₇H₂₁FN₂O₃

O=C(NNC1=CC=C(F)C=C1)COC2=C(C)CC(C)(C)CC2=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen H, et al. Discovery of Novel Isophorone Derivatives as Potential Succinate Dehydrogenase Inhibitors: Design, Synthesis, Antifungal Evaluation, and Action Mechanism. J Agric Food Chem. 2025 Sep 24;73(38):24416-24426.  [Content Brief]