2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. DHODH-IN-14

DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for rat liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.

For research use only. We do not sell to patients.

DHODH-IN-14 Chemical Structure

DHODH-IN-14 Chemical Structure

CAS No. : 1364791-93-4

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Based on 1 publication(s) in Google Scholar

DHODH-IN-14 Related Antibodies

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Description

DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for rat liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis[1].

IC50 & Target

IC50: 0.49 μM (Rat liver DHODH)[1]
Cellular Effect
Cell Line Type Value Description References
Jurkat IC50
59.7 μM
Compound: 2
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
[PMID: 28235702]
In Vitro

DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold with fluoro substituents. Moving to derivatives DHODH-IN-14, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-14 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-14 Related Antibodies
Molecular Weight

353.23

Formula

C15H7F4N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NONC1=O)NC2=C(F)C(F)=C(C3=CC=CC=C3)C(F)=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (353.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8310 mL 14.1551 mL 28.3102 mL
5 mM 0.5662 mL 2.8310 mL 5.6620 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8310 mL 14.1551 mL 28.3102 mL 70.7754 mL
5 mM 0.5662 mL 2.8310 mL 5.6620 mL 14.1551 mL
10 mM 0.2831 mL 1.4155 mL 2.8310 mL 7.0775 mL
15 mM 0.1887 mL 0.9437 mL 1.8873 mL 4.7184 mL
20 mM 0.1416 mL 0.7078 mL 1.4155 mL 3.5388 mL
25 mM 0.1132 mL 0.5662 mL 1.1324 mL 2.8310 mL
30 mM 0.0944 mL 0.4718 mL 0.9437 mL 2.3592 mL
40 mM 0.0708 mL 0.3539 mL 0.7078 mL 1.7694 mL
50 mM 0.0566 mL 0.2831 mL 0.5662 mL 1.4155 mL
60 mM 0.0472 mL 0.2359 mL 0.4718 mL 1.1796 mL
80 mM 0.0354 mL 0.1769 mL 0.3539 mL 0.8847 mL
100 mM 0.0283 mL 0.1416 mL 0.2831 mL 0.7078 mL
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DHODH-IN-14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-141364791-93-4Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHhydroxyfurazanLeflunomideA771726BQNratantiinflammatoryrheumatoidarthritisInhibitorinhibitorinhibit

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