2. MAPK/ERK Pathway Immunology/Inflammation
  3. MAP4K Interleukin Related
  4. HPK1-IN-57

HPK1-IN-57 (Compound 10c) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.09 nM. HPK1-IN-57 inhibits the activity of HPK1 kinase by forming ionic and hydrogen bonds with specific amino acid residues of the HPK1 protein, thereby hindering the phosphorylation of the downstream adaptor protein SLP76 (IC50 is 33.74 nM) and effectively stimulating the secretion of the T cell activation marker IL-2 (EC50 is 84.24 nM). HPK1-IN-57 is promising for research of tumor immunotherapy.

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HPK1-IN-57 Chemical Structure

HPK1-IN-57 Chemical Structure

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HPK1-IN-57 Related Antibodies

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Description

HPK1-IN-57 (Compound 10c) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.09 nM. HPK1-IN-57 inhibits the activity of HPK1 kinase by forming ionic and hydrogen bonds with specific amino acid residues of the HPK1 protein, thereby hindering the phosphorylation of the downstream adaptor protein SLP76 (IC50 is 33.74 nM) and effectively stimulating the secretion of the T cell activation marker IL-2 (EC50 is 84.24 nM). HPK1-IN-57 is promising for research of tumor immunotherapy[1].

Molecular Weight

594.66

Formula

C30H36F2N8O3
SMILES

O=C(N)C1=CN=C(NC2=CC=C(C(NC3CCC(F)(F)CC3)=O)C=C2)N=C1NC4=C(OC)C=C(N5CCN(C)CC5)C=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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HPK1-IN-57 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-57MAP4KInterleukin RelatedMAPK Kinase Kinase KinaseILHPK1SLP76tumor immunotherapyInhibitorinhibitorinhibit

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