NK-611  (Synonyms: VP 19)

NK-611 is an epipodophyllotoxin derivative. NK-611 induces DNA double-strand breaks by inhibiting topoisomerase II (IC₅₀ = 56 μM). NK-611 does not inhibit microtubule polymerization, thus avoiding the side effects of the parent compound, Podofilox (HY-15552). NK-611 exhibits broad-spectrum antitumor activity and demonstrates potent efficacy in in vivo models of leukemia. NK-611 can be used in cancer research^[1][2].

NK-611 (0.51-51 μM, 1 h- 28 d) exhibits potent cytotoxicity against L1210 cells with an IC₅₀ of 0.33 μM and also exhibits time-dependent broad-spectrum anti-tumor activity against 17 different types of tumors, including renal cell carcinoma and colorectal cancer^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NK-611 (i.p., single dose) exhibits significant anti-tumor activity in a mouse leukemia model with an ED₅₀ of 0.9 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

615.62

C₃₁H₃₇NO₁₂

105655-99-0

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@]7([H])[C@](CO[C@@H](C)O7)([H])O6)O)N(C)C)[C@@]2([H])CO1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Daley L, et al. Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. J Med Chem. 1998 Nov 5;41(23):4475-85.  [Content Brief]

  [2]. Hanauske AR, et al. Activity of NK 611, a new epipodophyllotoxin derivative, against colony forming units from freshly explanted human tumours in vitro. Eur J Cancer. 1995 Sep;31A(10):1677-81.