2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. HSP70-IN-7

HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs). HSP70-IN-7 can be used for the study of breast cancer.

For research use only. We do not sell to patients.

HSP70-IN-7

HSP70-IN-7 Chemical Structure

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HSP70-IN-7 Related Antibodies

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Description

HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs). HSP70-IN-7 can be used for the study of breast cancer[1].

IC50 & Target[1]

HSP70

4.71 μM (Ki)

In Vitro

HSP70-IN-7 (compound 5) (48 h) inhibits breast cancer cells proliferation with IC50 values of 0.793, 0.297, 0.863 and 0.6 μM against MDA-MB-231, BT549, MCF7 and CAMA1 cells[1].
HSP70-IN-7 (1 μM, 48 h) induces apoptosis in stable clones from NS/GRP75 shRNA-transfected BT549 cells[1].
HSP70-IN-7 (0.5-1 μM, 10-14 d) inhibits the colony formation and mammosphere formation of MDA-MB-231 cells[1].
HSP70-IN-7 (1 μM, 0-1 h) directly acts on mitochondrial GRP75, destroying its PPIs, thereby leading to mitochondrial membrane permeabilization and Cyt c release in BT549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSP70-IN-7 Related Antibodies

Apoptosis Analysis[1]

Cell Line: BT549 cells
Concentration: 1 μM
Incubation Time: 48 h
Result: Induced cell apoptosis.
Molecular Weight

958.08

Formula

C55H66BrN4O2PS
SMILES

CN(CCNC(C1=C2C3=CC=CC2=C(C=C1)SC4CCCCC4)=C(C3=O)C#N)CCNC(CCCCCCCCCCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O.[Br-]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSP70-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-7HSPApoptosisHeat shock proteinsSubcellular AnchoringIsoform-Selective Inhibition?Breast Cancer Stem CellsInhibitorinhibitorinhibit

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